The book is written for professionals and students interested batch fermentation process operations. It requires little background information in various areas such as biotechnology, statistics, system theory, and process control. Introductory materials in biotechnology can be found in various process engineering books [35, 426, 546]. Applied statistics books for engineers and scientists [78, 167, 400, 626] provide the basic theory and techniques. A reference for multivariate statistics [262] would be useful for Chapters 6 and 8. Several good textbooks are available for basic concepts in process control [366, 438, 541]. Advanced books in all these areas are referenced in appropriate chapters in the book.

Ideally, the chapters in this book should be read in the sequence they appear. However, allowing for potential diversity in background in fundamenCopyright © 2003 by Taylor & Francis Group, LLC

tals of various readers, we suggest here alternate roadmaps. Chapters 1 and 9, being the first and last chapters in this book, have been intentionally kept descriptive and can be followed by readers with diverse fundamental background and technical expertise with relative ease. The remaining chapters could be followed in the order in which they appear or in an alternate sequence. Readers with much more familiarity with process modeling and control than with statistical methods may start with Chapters 2, 5 and 7. This sequence would then be followed by Chapters 3 and 4, which deal with data collection and pretreatment and data-based modeling, This would then set the stage for statistical techniques for process monitoring and fault diagnosis, which are the subjects of Chapters 6 and 8. In this alternate sequence, the readers may need to refer to appropriate sections in Chapters 3 and 4 while going over certain sections of Chapters 5 and 7. Finally, readers very conversant with statistics and statistical methods but not familiar with engineering processes may start with Chapters 3 and 4 and may transit to Chapters 6 and 8, followed by Chapters 2, 5 and 7. Many chapters rely on sufficient knowledge of linear algebra and systems theory. The readers will be well served by referring to appropriate help material, as needed, on these, which can be found in many undergraduate and graduate texts in engineering and mathematics. Access to the help material will permit the readers to focus on differences in methodologies/techniques discussed in individual sections of the appropriate chapters. At the start of each chapter, we have provided a brief layout of the chapter. Depending on the level of familiarity with different sections in a chapter, the readers may make their own menu for going over the chapter, reading perhaps sections that they are more familiar with first, followed by reading the sections with which they are less familiar or unfamiliar. The book is intended to be a valuable resource guide. For further in-depth review of particular topics, the readers should access suggested references.

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