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[23, 24]

nature of cellular metabolism, rate expressions for cell replication, nutrient uptake and synthesis of metabolites of interest are usually analogous to those for individual enzyme-catalyzed reactions (Langmuir-Hinshelwood type). Some of the entries in Tables 2.1 and 2.2 are reflective of this.

The uncoupled, multiplicative form in Eq. 2.17, although by far the most popular, is not the only way of relating the specific cell growth rate (/i) to concentrations of various nutrients, cell mass and target metabolites. Alternate expressions for ¡i do not uncouple the effects of concentrations of individual species influencing cell growth. One such expression, used previously for description of growth of P. chrysogenum, the strain used for synthesis of penicillin, is the Contois kinetics, viz.,

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