Apoptosis And Animal Cell Biotechnology

At present, there are around 100 new biopharmaceuticals in phase I, II, and III clinical trials (79). Production of a biologically active therapeutic will, in many cases, necessitate expression of the protein in mammalian cell lines. As a result of intense commercial pressure, tried and tested production processes are often adopted in order to ensure that the product reaches the market in the shortest possible time. Initially, such production processes were relatively inefficient and there was tremendous scope for process optimization. Advances in cell biology, in addition

Table 1. Examples of Genes Involved in Apoptosis Table 2. Proteases Involved in the Induction of Apoptosis


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