Conclusions

In this article, we have illustrated how fusions to the immunoglobulin-binding domains of SpA and the serum albumin-binding regions of SpG, respectively, have become important tools in many fields of research. Several strategies for improved heterologous expression and simplified recovery are based on such gene fusions. We focused on some current trends in certain fields of applications for SpA and SpG fusion proteins. It is apparent that SpA and SpG fusion proteins will soon find extensive use in novel applications in medicine, immunology, and biotechnology.

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