For growth-associated products (i.e., a > f!) product concentration is proportional to biomass and is independent of the dilution rate when X is approximately constant. Increasing the dilution rate results in increased product formation up to the region near DC. The growth dependence of product formation and intracellular metabolic fluxes can be determined using a chemostat (10). An example of growth-associated product formation is shown in Figure 3 (11), in which product concentration is proportional to biomass and the growth dependence of qp is evident.
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