The influence of ammonia concentration on mammalian cell growth and product expression has been reported for a variety of cell lines and culture conditions (56). Most of these studies emphasized the influence of ammonia on cell growth. The effects of elevated ammonia concentrations on metabolic rates and cell productivity have been studied less extensively. Although it is not discussed in detail in this article, the effect of ammonia on virus replication and virus production from cell culture was demonstrated clearly in the literature (57-63).
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