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Source: From Ref. 16.

Source: From Ref. 16.

The biomass productivity of the CSTR can be compared to the productivity of a batch fermentor (RBATCH) by defining a relevant batch productivity. The batch fermentation cycle consists of a lag phase, an exponential growth phase, cell harvest, and a batch turnaround time associated with cleaning, sterilizing, and filling the vessel. The lag, harvest, and turnaround activities can be grouped into a term fTURNAROUND in order to determine the batch cycle time (tCYCLE) using equation 13, in which Xi is the concentration of cells in the vessel following inoculation (typically Xi ~ 0.1 x X).

Mmax \Xi

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