Fig. 8.21 Conversion of 1,4-butanediol with simultaneous separation of the products tetra-hydrofuran and water on a monolithic reactor: column length = 180 mm; column diameter = 12 mm

Polymer-Assisted Solution-Phase Organic Synthesis

Another very interesting field of application is polymer-assisted solution-phase synthesis. In this synthetic approach one of the reactants is fixed on the solid polymer support and the other reactant is added in solution [29]. Detailed review papers concerning aspects of polymer design for synthetic purposes have been published, but solid phase synthesis as a convenient laboratory method in organis synthesis emerged only recently [30-32]. The advantage of this method is that purification of the product mixture is simplified. By-products stay on the resin phase whereas the product solution leaves the reactor. To enhance the convenience of this method we developed microreactors consisting of a monolithic rod with a basic ion-exchange resin inside the pore volume [33]. These microreactors were used as batch reactors in recycling mode. In co-operation with others, several organic reactions could be performed covering reductions, oxidations, and nucleo-philic substitutions, as described in a paper published recently [34].

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