Amp

Site of the defective enzyme Biosynthetic route

Fig. 3.16. Control of the biosynthesis of the purine nucleotides in Bacillus subtilis. 1. Reaction catalysed by PRPP amidinotransferase. 2. Reaction catalysed by IMP dehydrogenase. 3. Reaction catalysed by adenylosuccinate synthase. AMP = Adenosine monophosphate. IMP = Inosine monophosphate XMP = Xanthine monophosphate. GMP = Guanosine monophosphate sine (Shibai et al. 1978) which is produced from auxotrophic strains of Bacillus subtilis The control of the production of purine nucleotides is shown in Fig. 3.16. The main sites of control shown in Fig. 3.16 are:

-• Feedback repression

Fig. 3.17. The control of the synthesis of purine nucleotides in a mutant with a defective adenylosuccinate synthase.

Fig. 3.17. The control of the synthesis of purine nucleotides in a mutant with a defective adenylosuccinate synthase.

Sites of the defective enzymes Biosynthetic route Feedback inhibition Feedback repression Control defective

Adenylosuccinate \ \ \ AMP

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