Cfv

11. Freeze drying

Fig. 10.5. Purification of micrococcal nuclease (Darbyshire, 1981).

Conformance to regulatory requirements. Waste treatment needs. Continuous or batch processing. Automation.

Personnel health and safety (Wildfeuer, 1985).

The major problem currently faced in product recovery is the large-scale purification of biologically active molecules. For a process to be economically viable large-scale production is required, and therefore large-scale separation, recovery, and purification. This then requires the transfer of small-scale preparative/analytical technologies (e.g. chromatographic techniques) to the production scale whilst maintaining efficiency of the process, bio-activity of the product and purity of the product so that it conforms with safety legislation and regulatory requirements. Developments in this field, and remaining areas for development are documented by Pyle (1990).

Overflow

Overflow

Foam breaker parger

Fig. 10.6. Schematic flow diagram for foam fractionation (Wane and Sinskey, 1970).

Foam breaker parger

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