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---9 Feedback control

---9 Feedback control

Fig. 3.9. The control of a biosynthetic pathway by sequential feedback control.

---• Feedback control

Fig 3-10. The control of two isoenzymes (catalysing the conversion of A to B) by end products D and F.

gested earlier, an understanding of the control of production of a metabolite may enable the construction of a 'blueprint' of the most useful industrial mutant, i.e. one where the production of the metabolite is not restricted by the organism's control system. Such postulated mutants may be modified in three ways:

1. The organism may be modified such that the end products which control the key enzymes of the pathway are lost from the cell due to some abnormality in the permeability of the cell membrane.

2. The organism may be modified such that it does not produce the end products which control the key enzymes of the pathway.

3. The organism may be modified such that it does not recognize the presence of inhibiting or repressing levels of the normal control metabolites.

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