The Selection Of Strains Which Are Tolerant Of Low Oxygen Tension

The provision of oxygen is frequently the limiting factor of many fermentations and it would, therefore, be desirable to select an organism which was capable of producing the product at a lower oxygen tension than normal. This may be achieved by screening for increased production under oxygen limited conditions. For example, Mindlin and Zaitseva (1966) isolated a lysine-producing strain which maintained its productivity under aeration conditions which decreased the parental strain productivity by almost a half.

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