This chapter presents a case study to show how modeling work can provide insights into how to best design and operate well-mixed rotating and stirred drum bioreactors. Recently, Schutyser et al. (2001, 2002, 2003c) have developed more sophisticated models for rotating-drum bioreactors. These models describe the movement of individual particles during drum operation. Although they are potentially quite powerful tools for exploring bioreactor behavior, they are much more complex to set up, and solution times can be as long as several days.

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